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Please use this identifier to cite or link to this item: http://hdl.handle.net/10466/3076

Title: Microbial Contamination of the Crude Drugs "Senna Leaf" and Their Radiation Sensitivity to Gamma-Ray Irradiation
Authors: OHNISHI, Tokuhiro
OKAMOTO, Shinichi
KIMURA, Syojiro
Issue Date: 31-Mar-1998
Publisher: Osaka Prefecture University
Citation: Bulletin of Osaka Prefecture University. Ser. B, Agriculture and life sciences. 1998, 50, p.67-74
Abstract: The numbers of microorganisms adhering to the crude drug "Senna Leaf" and radiation sensitivity of them were investigated. Total aetobic microbial counts of ten kinds of Senna Leaf were determined to be in the range from 10^3 to 10^4 CFU/g for bacteria and from 10^1 to 10^3 CFU/g for fungi. The orders of these values were higher than the synthetic compound. Most of survival curves obtained in this experiment were sigmoidal. The induction dose (ID) was obtained from the shoulder portion of each curve, the D_2 value was obtained from the gradient of the linear portion of each curve and the inactivation factor (IF) was calculated from the sigmoid curve. The average values of ID, D_2 and IF for bacteria were 2.9kGy, 1.0kGy and 8.1kGy respectively. From this experiment, the average SD value required for attaining the contamination level provided by the USP Forum (total bacteria count<20/g) was estimated to be 6kGy. The numbers of fungi becomes less than 10CFU/g under this condition.
URI: http://hdl.handle.net/10466/3076
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